4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers),4-Hydroxy Valproic Acid Sodium Salt,1216888-06-0

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产品名称：4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers)

产品别名：4-Hydroxy-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-4-hydroxypentanoic Acid Sodium Salt

CAS号：1216888-06-0

英文别名：4-Hydroxy-2-propyl-pentanoic Acid Sodium Salt; 2-Propyl-4-hydroxypentanoic Acid Sodium Salt

分子量：182.19

分子式：C₈H₁₅O₃•Na

纯度：见爱必信官网

外观：见爱必信官网

保存方法：Store at -20° C

描述：4-Hydroxy Valproic Acid Sodium Salt(Mixture of Diastereomers) is a racemic mixture of metabolites of Valproic Acid. In the metabolism of Valproic Acid to 4-Hydroxy Valproic Acid, it has been reported that CYP4B1 may play a role in this conversion, as demonstrated using monospecific polyclonal antibodies directed against CYP4B1. Valproic Acid is a branched chain, fatty acid which is reported to potentially enhance central GABAergic neurotransmission and inhibit Na⁺ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. In animal studies, Valproic Acid has been observed to reduce tumor growth and metastasis formation. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A in the inhibition of histone deacetylase.

Metabolites of Valproic Acid are also available as:
Valproic Acid
Valproic Acid, Sodium Salt
3-Hydroxy Valproic Acid
3-Keto Valproic Acid Sodium Salt
rac 5-Hydroxy Valproic Acid Sodium Salt
Valproic Acid β-D-Glucuronide Allyl Ester
Valproic Acid β-D-Glucuronide

Labelled forms of Valproic Acid are available as:
Valproic Acid-d6
Valproic Acid-d6 β-D-Glucuronide
rac 5-Hydroxy Valproic Acid-d7 Sodium Salt

应用：A metabolite of the HDAC inhibitor Valproic acid

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