Anti-CRIPT突触后蛋白CRIPT抗体

本公司提供科研CRIPT突触后蛋白CRIPT抗体，抗体质量可靠，订购CRIPT突触后蛋白CRIPT抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：突触后蛋白CRIPT抗体
英文名称：Anti-CRIPT
货号：bs-11021R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 11kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. These proteins are physically and functionally linked to cytoskeletal and/or signaling proteins. CRIPT (for cysteine-rich interactor of PDZ three), a novel postsynaptic protein, binds specifically to the PDZ3 domain of PSD-95/SAP 90. CRIPT induces the recruitment of PSD-95/SAP 90 to microtubules, and it has been shown to bind directly to microtubules, indicating that it may be responsible for cytoskeletal anchoring of PSD-95/SAP 90. CRIPT is widely expressed outside of the brain and is highly conserved from animals to plants suggesting a wider role in regulating cytoskeleton-membrane associations.Function : Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.Subcellular Location : Cytoplasm. Cell junction > synapse. Cell projection > dendritic spine. Colocalizes with DLG4 in asymmetric synapses.