Anti-Podoplanin Protein/gp36平足蛋白抗体(淋巴管内皮细胞蛋白)

本公司提供科研Podoplanin Protein/gp36平足蛋白抗体(淋巴管内皮细胞蛋白)，抗体质量可靠，订购Podoplanin Protein/gp36平足蛋白抗体(淋巴管内皮细胞蛋白)请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：平足蛋白抗体(淋巴管内皮细胞蛋白)
英文名称：Anti-Podoplanin Protein/gp36
货号：bs-1048R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 15kDa
纯化方法：affinity purified by Protein A
交叉反应：mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Podoplanin May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.Function : May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.Subcellular Location : Membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.Tissue Specificity : Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.Post-translational modifications : Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.The N-terminus is blocked.Similarity : Belongs to the podoplanin family.Podoplanin Protein是一种肾小球足状突细胞膜粘蛋白，目前已成为一种新的淋巴管内皮标记物蛋白，在少数小静脉上也有表达。 podoplanin Protein是淋巴管内皮高度敏感且特异性的标记物，作为肿瘤细胞的血小板聚集介导因子而发挥作用，能促进肿瘤细胞迁移及增加肿瘤细胞侵袭力。