Anti-CD71/TFR/Transferrin receptor转铁蛋白受体抗体

本公司提供科研CD71/TFR/Transferrin receptor转铁蛋白受体抗体，抗体质量可靠，订购CD71/TFR/Transferrin receptor转铁蛋白受体抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：转铁蛋白受体抗体
英文名称：Anti-CD71/TFR/Transferrin receptor
货号：bs-0988R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 74/85kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Cellular uptake of iron occurs via receptor mediated endocytosis of ligand occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Useful in studies of dividing haematopoietic and tumour cell populations, and metabolic activity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C terminal binding site. The antigen is present on most dividing cells, including normally cycling in vivo hematopoietic progenitor cells, mitogenically stimulated cells in vitro, some primary tumor cells and most proliferating cells in vitro.Subunit : Homodimer; disulfide-linked. Binds one transferrin molecule per subunit.Interacts with SH3BP4.Subcellular Location : Cell membraneSimilarity : Belongs to the peptidase M28 family. M28B subfamily.转铁蛋白及转铁蛋白受体(TfnrR)是机体铁代谢中的重要因子，铁是细胞生长增殖、代谢的必需元素,转铁蛋白受体(TfR)介导的胞吞作用是细胞摄取铁的主要途径。肿瘤细胞因增殖生长旺盛,对铁的需求高,所以肿瘤细胞有比正常细胞更多的转铁蛋白受体的表达。产品图片Antigen: bs-0988P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.