Anti-p70 S6 kinase alpha磷酸化核糖体p70 S6蛋白激酶抗体

本公司提供科研p70 S6 kinase alpha磷酸化核糖体p70 S6蛋白激酶抗体，抗体质量可靠，订购p70 S6 kinase alpha磷酸化核糖体p70 S6蛋白激酶抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化核糖体p70 S6蛋白激酶抗体
英文名称：Anti-p70 S6 kinase alpha
货号：bs-6370R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 70kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, hrs, dog, chk, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：In studies to elucidate key regulatory pathways in signal transduction, several protein serine/threonine (Ser/Thr) kinases have been identified. Included among such kinases are two distinct families of 40S ribosomal protein S6 Ser/Thr kinases present in somatic animal cells, designated p70 S6 kinase and p90 Rsk kinase. p90 Rsk kinase is maximally activated within minutes of addition of growth factors or phorbol ester to cultured cells followed by activation of p70 S6 kinase. Both enzymes are regulated by serine/threonine phosphorylation, suggesting that specific kinases may exist upstream in the signaling pathway that regulate these kinases. In fact, evidence suggests that one such family of activating enzymes includes the members of the ERK MAP kinase family. The ERK MAP kinases are, in turn, regulated by phosphorylation at threonine and tyrosine residues by a protein kinase designated MEK.Subunit : Interacts with PPP1R9A/neurabin-1.Subcellular Location : Cell junction, synapse, synaptosome. Mitochondrion outer membrane. Isoform Alpha I: Nucleus. Cytoplasm. Isoform Alpha II: Cytoplasm.Tissue Specificity : Widely expressed.Similarity : Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.Contains 1 AGC-kinase C-terminal domain.Contains 1 protein kinase domain.