Anti-ARH/LDL receptor adaptor protein低密度脂蛋白受体衔接蛋白抗体

本公司提供科研ARH/LDL receptor adaptor protein低密度脂蛋白受体衔接蛋白抗体，抗体质量可靠，订购ARH/LDL receptor adaptor protein低密度脂蛋白受体衔接蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：低密度脂蛋白受体衔接蛋白抗体
英文名称：Anti-ARH/LDL receptor adaptor protein
货号：bs-6337R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 34kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, k, cow, dog, Zebrafish
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：FunctionAdapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.Tissue specificity: Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.