Anti-ACPT睾丸酸性磷酸酶抗体

本公司提供科研ACPT睾丸酸性磷酸酶抗体，抗体质量可靠，订购ACPT睾丸酸性磷酸酶抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：睾丸酸性磷酸酶抗体
英文名称：Anti-ACPT
货号：bs-6289R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 47kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, hrs
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is upregulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. ACPT dephosphorylates receptor tyrosine-protein kinase erbB-4 and inhibits the ligand-induced proteolytic cleavage. ACPT is predominantly expressed in testis but exhibits a lower level of expression in testicular cancer tissues than in normal tissues. ACPT has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.Subcellular Location : Membrane; Single-pass type II membrane protein (Potential).Tissue Specificity : High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract.Similarity : Belongs to the peptidase S1 family.Contains 1 LDL-receptor class A domain.Contains 1 peptidase S1 domain.Contains 1 SRCR domain.