Anti-DAB2信号转导功能磷蛋白DAB2抗体

本公司提供科研DAB2信号转导功能磷蛋白DAB2抗体，抗体质量可靠，订购DAB2信号转导功能磷蛋白DAB2抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：信号转导功能磷蛋白DAB2抗体
英文名称：Anti-DAB2
货号：bs-5999R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 83/59/102kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].Dab2/DOC-2是具有信号转导功能的磷蛋白,在丝裂原信号转导途径中起作用,通过蛋白质的相互作用和蛋白磷酸化而发挥作用，Dab2还参与控制细胞生长的信号通路-发挥生长YZ效应。Dab2/DOC-2又作为胞质衔接蛋白,参与细胞内蛋白运输。在肿瘤中纯合子基因缺失时被激活,是抑癌基因的候选成员。Dab2在多种肿瘤中低或失表达,如卵巢癌,乳腺癌,绒毛膜癌和前列腺癌等,重新表达能YZ肿瘤的生长。Dab2也在胚胎的发生过程中发挥重要的作用。