Anti-Robo4肿瘤血管内皮调节蛋白Robo4抗体

本公司提供科研Robo4肿瘤血管内皮调节蛋白Robo4抗体，抗体质量可靠，订购Robo4肿瘤血管内皮调节蛋白Robo4抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：肿瘤血管内皮调节蛋白Robo4抗体
英文名称：Anti-Robo4
货号：bs-5795R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 108kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, pig, dog, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Robo4 is a vascular specific receptor that is a repulsive cue to migrating endothelial cells during vascular development. Guidance and patterning of axons are orchestrated by cell surface receptors and ligands that provide directional cues. Interactions between the Robo receptor and Slit ligand families of proteins initiate signaling cascades that repel axonal outgrowth. In contrast to known neuronal Robo family members, the arrangement of the extracellular domains of Robo4 diverges significantly from that of all other Robo family members. Robo4 is specifically expressed in the vascular endothelium during murine embryonic development; the only Robo family member expressed in primary endothelial cells. Robo4 also has a role in regulating the migration of endothelial cells during tumor angiogenesis.Function : Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit protein.Subunit : Interacts with SLIT2 and ENAH.Tissue Specificity : Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.Similarity : Belongs to the immunoglobulin superfamily. ROBO family.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains.Database links : UniProtKB/Swiss-Prot: Q8WZ75.1Gene ID: 54538(human)