Anti-phospho-RUNX2(Ser451)磷酸化成骨特异性转录因子抗体

本公司提供科研phospho-RUNX2(Ser451)磷酸化成骨特异性转录因子抗体，抗体质量可靠，订购phospho-RUNX2(Ser451)磷酸化成骨特异性转录因子抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化成骨特异性转录因子抗体
英文名称：Anti-phospho-RUNX2(Ser451)
货号：bs-5685R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 67kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, pig, hrs, cow, chk, dog
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation.Subunit : Heterodimer of an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with G22P1 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4.Subcellular Location : Nucleus.Tissue Specificity : Specifically expressed in osteoblasts.Similarity : Contains 1 Runt domain.RUNX2又称：Cbfα1(Core-binding factor, alpha 3 subunit) 是新发现的一类调控间充质干细胞向成骨方向分化的特异性转录因子,参与骨形成,骨骼生长和发育的一类重要细胞,它起源于多能间充质干细胞,是间充质干细胞在体内的各种调控因素的调节下发育而成的。