Anti-Phospho-Tuberin/TSC2(Ser540)磷酸化结节性硬化蛋白抗体

本公司提供科研Phospho-Tuberin/TSC2(Ser540)磷酸化结节性硬化蛋白抗体，抗体质量可靠，订购Phospho-Tuberin/TSC2(Ser540)磷酸化结节性硬化蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化结节性硬化蛋白抗体
英文名称：Anti-Phospho-Tuberin/TSC2(Ser540)
货号：bs-5608R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 200kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Tuberin, or TSC2 (Tuberous sclerosis complex), is implicated as a tumor suppressor. It may function in vesicular transport, and may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between hamartin (TSC1) and tuberin may facilitate vesicular docking. It specifically stimulates the intrinsic GTPase activity of the Ras related protein RAP1A and RAB5, suggesting a possible mechanism for its role in regulating cellular growth. Mutations in tuberin lead to constitutive activation of RAP1A in tumors. At least three isoforms of Tuberin exist.Tuberin 为180kD-220的蛋白产生于结节性硬化（TSC-2）位于染色体16的基因。结节性硬化为常染色体疾病已知为斑痣性错构瘤病其特征为广泛性发展呈良性生长，在许多组织与器官中描述为错构瘤。Tuberin被认为在GTPase活动性蛋白中起作用调节细胞内吞与作为肿瘤YZ子。Tuberin低水平广泛性表达在大多数组织中，而在皮层神经元、小脑浦肯野氏细胞、脊索运动神经元、胰岛B细胞、心肌、肾脏与皮肤的小血管中表达增加。