Anti-Phospho-PPAR Gamma (ser112)磷酸化过氧化酶活化增生受体γ抗体

本公司提供科研Phospho-PPAR Gamma (ser112)磷酸化过氧化酶活化增生受体γ抗体，抗体质量可靠，订购Phospho-PPAR Gamma (ser112)磷酸化过氧化酶活化增生受体γ抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化过氧化酶活化增生受体γ抗体
英文名称：Anti-Phospho-PPAR Gamma (ser112)
货号：bs-3737R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 52kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Gpig, dog, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008].Subunit : "Forms a heterodimer with the retinoic acid receptor RXRA called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with FAM120B. Interacts with PRDM16 (By similarity). Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 LXXLL motifs. Interacts with DNTTIP2, MAP2K1/MEK1, PRMT2 and TGFB1I1. Interacts with PDPK1. Interacts with ASXL1 AND ASXL2.Subcellular Location : Nucleus. Cytoplasm.Tissue Specificity : Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.Similarity : Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.类固醇受体（Steroid Receptors）过氧化物酶体增殖物激活受体γ（PPARγ）主要存在于白色脂肪组织，PPARγ对于脂肪生成、血糖稳定、炎症反应、动脉粥样硬化和肿瘤等的发生都起到重要的作用。主要在脂肪细胞内表达。PPARγ是噻唑烷二酮类药物（TZDs）作用的药靶，又是脂肪细胞分化的重要调节因子。经研究发现，PPARγ在肥胖及胰岛素抵抗的发病机制中具有十分重要的意义，是ZL糖尿病、肥胖等代谢性疾病的重要药靶。过氧化物酶体增殖物激活受体γ（PPARγ）属Ⅱ型核受体超家族成员，主要在脂肪细胞内表达。PPARγ是噻唑烷二酮类药物（TZDs）作用的药靶，又是脂肪细胞分化的重要调节因子。现有研究（包括一次于美国加州大学进行的研究）发现PPARγ在肥胖及胰岛素抵抗的发病机制中具有十分重要的意义，是ZL糖尿病、肥胖等代谢性疾病的重要药靶。目前，该受体蛋白质水平的筛选模式已经建立，并正在建立该受体的报告基因的细胞水平筛选评价模式。