Anti-Phospho-Torc1/Crtc1 (Ser151)磷酸化CREB转录共激活因子TORC1抗体

本公司提供科研Phospho-Torc1/Crtc1 (Ser151)磷酸化CREB转录共激活因子TORC1抗体，抗体质量可靠，订购Phospho-Torc1/Crtc1 (Ser151)磷酸化CREB转录共激活因子TORC1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化CREB转录共激活因子TORC1抗体
英文名称：Anti-Phospho-Torc1/Crtc1 (Ser151)
货号：bs-3453R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 70kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, hrs, chk, pig, dog, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.Subunit : Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1. 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction. Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1. Binds HTLV1 Tax.Subcellular Location : Cytoplasm. Nucleus.Tissue Specificity : Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.Similarity : Belongs to the TORC family.