Anti-Phospho-NPM (Ser4)磷酸化核仁磷酸蛋白抗体

本公司提供科研Phospho-NPM (Ser4)磷酸化核仁磷酸蛋白抗体，抗体质量可靠，订购Phospho-NPM (Ser4)磷酸化核仁磷酸蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化核仁磷酸蛋白抗体
英文名称：Anti-Phospho-NPM (Ser4)
货号：bs-3308R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 38kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Nucleophosmin (NPM) also called B23, nutramin and NO38 is a ubiquitously expressed phosphoprotein involved in ribosome assembly/transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53. It is involved in the acute response of mammalian cells to environmental stress, such as UV rays. NPM continuously shuttles between the nucleus and cytoplasm. It has been shown to bind nucleic acid, prevent protein aggregation via its chaperone activities, protect enzymes during thermal denaturation, and facilitate renaturation of chemically denatured proteins. In its cellular structure role, there is evidence suggesting NPM is associated with the centrosome. It is the substrate of CDK2/cyclin E during duplication of centrosomes (cellular division).Because of NPM gene interaction with several tumor-associated chromosome translocations, NPM is thought to be a portion of several fusion proteins: NPM-ALK, NPM-RAR, and NPM-MLF1. While it is not thought to be part of the transforming potential of these fusion proteins, it is believed to act as the interface for oligomerization and oncogenic conversion of these tumor promoting fusion proteins.核仁磷酸蛋白（nucleophosmin）是雌激素调控的一种核仁蛋白， Nucleophosmin(又称为NPM、B23、Numatrin、NO38)位于核仁的颗粒区,与其他一些核蛋白如C23、P120等可相互作用。 NPM可以在细胞核与细胞浆之间穿梭,其定位受细胞周期及一些细胞物的影响。NPM基因在多种人类肿瘤中过表达,因此被公认为肿瘤标志物和癌基因.后来研究发现NPM也具有YZ肿瘤的功能,它的缺失、突变甚至重排与多种肿瘤的发生密切相关.