Anti-Phospho-Jak3 (Tyr785)磷酸化蛋白酪氨酸激酶JAK-3抗体

本公司提供科研Phospho-Jak3 (Tyr785)磷酸化蛋白酪氨酸激酶JAK-3抗体，抗体质量可靠，订购Phospho-Jak3 (Tyr785)磷酸化蛋白酪氨酸激酶JAK-3抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化蛋白酪氨酸激酶JAK-3抗体
英文名称：Anti-Phospho-Jak3 (Tyr785)
货号：bs-3207R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 125kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, cow, pig, hrs
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.