Anti-Phospho-Histone H3 (Thr11)磷酸化组蛋白H3抗体

本公司提供科研Phospho-Histone H3 (Thr11)磷酸化组蛋白H3抗体，抗体质量可靠，订购Phospho-Histone H3 (Thr11)磷酸化组蛋白H3抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化组蛋白H3抗体
英文名称：Anti-Phospho-Histone H3 (Thr11)
货号：bs-3188R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 15kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo, cow, Rb, pig, fruit fly
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fibre is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. Covalent modifications of the canonical core histones, including acetylation, phosphorylation, methylation, and monoubiquitination are used to mark nucleosomes to create chromatin domains with a range of functions. The information encoded by histone modifications can contribute to the formation and/or maintenance of transcriptionally active and inactive chromatin in response to various signalling pathways.蛋白的基因非常保守,在亲缘关系较远的种属中, 四种组蛋白(H2A、H2A、H3、H4)氨基酸序列都非常相似, 如海胆组织H3的氨基酸序列与来自小牛胸腺的H3的氨基酸序列间只有一个氨基酸的差异, 小牛胸腺的H3的氨基酸序列与豌豆的H3也很相似。组蛋白是细胞核内的一种碱性核蛋白，抗组蛋白抗体即是以组蛋白为靶抗原的一种自身，是抗核抗体的一种.主要与药物性红斑狼疮、系统性红斑狼疮、类风湿关节炎有关.