Anti-Phospho-Beta-Catenin (Ser675)磷酸化β 连环素蛋白抗体

本公司提供科研Phospho-Beta-Catenin (Ser675)磷酸化β 连环素蛋白抗体，抗体质量可靠，订购Phospho-Beta-Catenin (Ser675)磷酸化β 连环素蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化β 连环素蛋白抗体
英文名称：Anti-Phospho-Beta-Catenin (Ser675)
货号：bs-3087R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 92kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, pig, hrs, cow, shp, chk, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：This gene encodes not only an important cytoplasmic component of the classical cadherin adhesion complex that forms the adherens junction in epithelia and mediates cell-cell adhesion in many other tissues but also a key signaling molecule in the canonical Wnt signaling pathway that controls cell growth and differentiation during both normal development and tumorigenesis. The gene product contains a central armadillo-repeat containing domain through which it binds the cytoplasmic tail of classical cadherins; meanwhile, it also binds alpha-catenin, which further links the cadherin complex to the actin cytoskeleton either directly or indirectly. Beta-catenin is therefore necessary for the adhesive function of classical cadherins. Subcellular Location : "Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction. Cell membrane. Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle pole.Tissue Specificity : Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon.Similarity : Belongs to the beta-catenin family.Contains 12 ARM repeats.细胞粘附蛋白（Call Adhesion Protein） β连环素蛋白β-catenin是一种多功能的蛋白质，能链接E-\N-,钙粘附分子具有参与细胞粘附和介导信号转导的双重功能，并与肿瘤的发SF展及浸润密切相关。 在正常个体中，β-catenin和钙黏蛋白形成复合体，介导同型细胞的粘附，维持细胞的稳定；同时，β-catenin作为Wnt/β-catenin信号通路的关键成员在介导信号转导过程中调控细胞的增殖和凋亡。 在恶性肿瘤中，β-catenin的表达呈现明显的异质性，促使细胞异常增殖，还可使细胞之间的黏附性减弱，侵袭性增强。