Anti-Noggin指(趾)关节粘连NOG蛋白抗体

本公司提供科研Noggin指(趾)关节粘连NOG蛋白抗体，抗体质量可靠，订购Noggin指(趾)关节粘连NOG蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：指(趾)关节粘连NOG蛋白抗体
英文名称：Anti-Noggin
货号：bs-2975R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 23kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, cow, hrs, shp
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities, with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs, Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7, and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes, including embryonic dorsal-ventral axis, induction of neural tissue, formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4, along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development, joint formation, and neural tube fusion.Subunit : Homodimer.Subcellular Location : Secreted.Similarity : Belongs to the noggin family.