Anti-DARPP32多巴胺、cAMP调节磷蛋白抗体

本公司提供科研DARPP32多巴胺、cAMP调节磷蛋白抗体，抗体质量可靠，订购DARPP32多巴胺、cAMP调节磷蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：多巴胺、cAMP调节磷蛋白抗体
英文名称：Anti-DARPP32
货号：bs-2762R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 23kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, dog, cow, hrs, pig, Gpig
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：DARPP32 is expressed in medium sized spiny neurons that also express dopamine D1 receptors. The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 and phosphorylated DARPP32 is a potent protein phosphatase 1. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho DARPP32, thereby reducing the phosphatase 1 inhibitory activity of DARPP32.Subcellular Location : Cytoplasm.Similarity : Belongs to the protein phosphatase inhibitor 1 family.DARPP-32通过自身不同位点的磷酸化对蛋白质磷酸化和去磷酸化过程发挥着双向调控的作用.DARRP-32在脑内存在于接受多巴胺能投射的神经元中,其磷酸化过程受多种神经递质的调控,在信号转导途径中处于ZX位置,整合多种胞内信号转导,调节神经元的电学和化学性质以及动物的生理行为反应,参与多种生理功能和病理过程,包括药物成瘾、抑郁症、精神分裂症等.此外,DARPP-32在非神经系统的功能也逐渐被人们所认识. 多巴胺和cAMP调节的磷蛋白(dopamine and adenosine 3'5'-monophosphate-regulated phospho-protein,Mr 32 kD,DARPP-32)是一个具有双重功能的独特蛋白,它既是磷酸酶(如PP-1)的YZ剂,也是蛋白激酶(如PKA)的YZ剂。