Anti-Cortactin皮层肌动蛋白抗体

本公司提供科研Cortactin皮层肌动蛋白抗体，抗体质量可靠，订购Cortactin皮层肌动蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：皮层肌动蛋白抗体
英文名称：Anti-Cortactin
货号：bs-2760R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 61kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, chk, hrs, Rb, cow
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq].Cortactin is an 80/85 kDa cytoskeleton protein that facilitates assembly of cortical actin. Cortactin is widely expressed in most adherent cells and is a prominent substrate of protein tyrosine kinase Src in vivo and in vitro. The protein sequence of cortactin contains multiple amino terminal tandem repeats of a unique 37 amino acid sequence, which associates with actin, and a Src homology 3 (SH3) domain at the carboxyl terminus. Between the repeat and the SH3 domain, there is an alpha helical structure followed by a proline rich region. Between the proline rich region and the SH3 domain, there are a series of Src phosphorylation sites (Tyr421, Tyr470, and Tyr486). In vitro, cortactin binds to and cross links F actin into meshworks. 皮层肌动蛋白（cortactin）是一种微丝肌动蛋白结合蛋白,其主要参与细胞骨架系统的调控,细胞外信号转导以及细胞黏附等过程，cortactin与肿瘤的侵袭和转移有关。