Anti-CR1/CD35Ⅰ型补体受体抗体（C3b/C4b受体抗体）

本公司提供科研CR1/CD35Ⅰ型补体受体抗体（C3b/C4b受体抗体），抗体质量可靠，订购CR1/CD35Ⅰ型补体受体抗体（C3b/C4b受体抗体）请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：Ⅰ型补体受体抗体（C3b/C4b受体抗体）
英文名称：Anti-CR1/CD35
货号：bs-2596R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 274kDa
纯化方法：affinity purified by Protein A
交叉反应：hu
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.Subunit : Monomer.Subcellular Location : Membrane; Single-pass type I membrane protein.Tissue Specificity : Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.Similarity : Belongs to the receptors of complement activation (RCA) family.Contains 30 Sushi (CCP/SCR) domains. CD35广泛分布于红细胞、粒细胞、单核细胞、肥大细胞、滤泡树突状细胞、肾小球足突细胞、B细胞及部分CD4+T细胞表面.CD35抗原又称为CR1或者C3b/C4b R，是一种分子量160-250kDa的C3b/C4b补体结合跨膜蛋白，主要用于滤泡树突状细胞标记和滤泡树突状细胞瘤的诊断。