Anti-PERK蛋白激酶样内质网激酶抗体

本公司提供科研PERK蛋白激酶样内质网激酶抗体，抗体质量可靠，订购PERK蛋白激酶样内质网激酶抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：蛋白激酶样内质网激酶抗体
英文名称：Anti-PERK
货号：bs-2469R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 125kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：PERK is a GCN2 Ser/Thr protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2) leading to its inactivation. This results in a reduction of translational initiation and repression of global protein synthesis. Expression of this Type I membrane protein is ubiquitous at low levels but greatest expression is seen in secretory and endocrine tissues. Defects in EIF2AK3 are the cause of Wolcott-Rallison syndrome (WRS), which is a rare autosomal recessive disorder.信号传导（Signaling Intermediates）