Anti-VAMP1/Synaptobrevin-1VAMP1囊泡相关膜蛋白1抗体

本公司提供科研VAMP1/Synaptobrevin-1VAMP1囊泡相关膜蛋白1抗体，抗体质量可靠，订购VAMP1/Synaptobrevin-1VAMP1囊泡相关膜蛋白1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：VAMP1囊泡相关膜蛋白1抗体
英文名称：Anti-VAMP1/Synaptobrevin-1
货号：bs-1950R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 13kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, hrs, cow, pig, dog, Gpig, Rb, chk
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：The Vesicle Associated Membrane Proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer's disease, VAMP levels of all isoforms appear to be significantly lowered. It has been shown that the extreme carboxy-terminus of VAMP1 is involved in subcellular vesicle targeting.Function : Involved in the targeting and/or fusion of transport vesicles to their target membrane.Subcellular Location : Mitochondrion outer membrane; Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome and Cytoplasmic vesicle membrane. Cell junction > synapse > synaptosome.Tissue Specificity : Nervous system, skeletal muscle and adipose tissue.Similarity : Belongs to the synaptobrevin family.Contains 1 v-SNARE coiled-coil homology domain.