Anti-PAI-2/SerpinB2纤溶酶原激活物YZ因子2抗体（血浆酶原激活酶YZ因子-2）

本公司提供科研PAI-2/SerpinB2纤溶酶原激活物YZ因子2抗体（血浆酶原激活酶YZ因子-2），抗体质量可靠，订购PAI-2/SerpinB2纤溶酶原激活物YZ因子2抗体（血浆酶原激活酶YZ因子-2）请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：纤溶酶原激活物YZ因子2抗体（血浆酶原激活酶YZ因子-2）
英文名称：Anti-PAI-2/SerpinB2
货号：bs-1864R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 47kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, Rb, pig, dog, cow
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：SerpinB2 is a serine proteinase inhibitor of the ovalbumin like B clade of serpins. It was first discovered in the placenta, and given the name PAI-2 because of the ability to inhibit urokinase plasminogen activator (u-PA) at low micromolar efficiency. SerpinB2 also inhibits tissue plasminogen activator (t-PA), but with micromolar efficiency, and PAI-1 is much more efficient that SerpinB2 on both forms of plasminogen activator. The structure of PAI-2 is not terribly similar to PAI-1, however, which is an E clade serpin. SerpinB2 is made by many cell types, and is found intracellularly as an unglycosylated kDa protein, and secreted as a 60 kDa protein. SerpinB2 is found in saliva, secreted by gingival fibroblasts, and in the skin. SerpinB2 levels are elevated in serum during pregnancy, and in leukemia, breast cancer and ovarian cancer, although it was lowered in some cancers.A shorter SerpinB2 isoform of 382 amino acids, has been reported, with a predicted mass of 43.1 kDa and a pI of 5.69. The shorter form has a deletion just after the start of the mature protein, but it is unclear what the relative production and distribution is for the shorter sequence.Subunit : Interacts with PSMB1.Subcellular Location : Cytoplasm. Secreted, extracellular space.Similarity : Belongs to the serpin family. Ov-serpin subfamily.