Anti-GRP78/BIP/HSPA5葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5）

本公司提供科研GRP78/BIP/HSPA5葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5），抗体质量可靠，订购GRP78/BIP/HSPA5葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5）请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：葡萄糖调节蛋白78抗体（热休克蛋白70蛋白5）
英文名称：Anti-GRP78/BIP/HSPA5
货号：bs-1219R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 78kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor. Function : Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.Subcellular Location : Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.DISEASE : Note=Autoantigen in rheumatoid arthritis.Similarity : Belongs to the heat shock protein 70 family.葡萄糖调节蛋白78是热休克蛋白70家族的成员之一又称：热休克蛋白70蛋白5,作为一种分子伴侣在蛋白质的折叠和转运过程及内质网应激反应中发挥重要作用.它在多种肿瘤组织中呈高表达.产品图片Antigen: bs-1219P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; TMB(C-0024) staining; Read the data in MicroplateReader by 450nm.