Anti-DCAMKL1丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体

本公司提供科研DCAMKL1丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体，抗体质量可靠，订购DCAMKL1丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：丝氨酸/苏氨酸蛋白激酶DCAMKL1抗体
英文名称：Anti-DCAMKL1
货号：bs-11455R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 82kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Lissencephaly (smooth brain) is an abnormality of brain development characterized by incomplete neuronal migration and a smooth cerebral surface, manifesting as severe mental retardation. Genetic analysis has identified two proteins that are mutated in some cases of lissencephaly, designated lissencephaly-1 protein (LIS1) and doublecortin. LIS1 displays sequence homology to ?subunits of heterotrimeric G proteins, and doublecortin contains a consensus Abl phosphorylation site. In addition, the DCAMKL1 (doublecortin-like and CAM kinase-like 1) protein shows homology to doublecortin. All three proteins are highly expressed in developing brain and may function together to regulate microtubules involved in neuronal migration. The DCAMKL1 protein encodes a functional kinase that is capable of phosphorylating myelin basic protein and itself, but its kinase activity does not appear to affect its microtubule polymerization activity.Function : Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.Tissue Specificity : In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.Contains 2 doublecortin domains.Contains 1 protein kinase domain.