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HOXA4同源盒基因HOXA4蛋白抗体,抗体质量可靠,订购
HOXA4同源盒基因HOXA4蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称:
同源盒基因HOXA4蛋白抗体英文名称:
Anti-HOXA4货号:bs-11293R
抗体来源:兔
克隆类型:多克隆
蛋白分子量:predicted molecular weight: 34kDa
纯化方法:affinity purified by Protein A
交叉反应:hu, mo, rat
测试应用:ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍:The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. HoxA4 (homeobox A4), also known as HOX1D or HOX1, is a 320 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Expressed in the embryonic nervous system, HoxA4 functions as a sequence-specific DNA-binding transcription factor that is part of a regulatory mechanism that provides cells with positional identities during development. Via its ability to bind DNA, HoxA4 plays an important role in the regulation of gene expression, as well as morphogenesis and differentiation. The gene encoding HoxA4 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.Function : Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.Subcellular Location : Nucleus.Tissue Specificity : Embryonic nervous system.Similarity : Belongs to the Antp homeobox family. Deformed subfamily.Contains 1 homeobox DNA-binding domain.