Anti-BRD7鼻咽癌相关转录调节蛋白抗体

本公司提供科研BRD7鼻咽癌相关转录调节蛋白抗体，抗体质量可靠，订购BRD7鼻咽癌相关转录调节蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：鼻咽癌相关转录调节蛋白抗体
英文名称：Anti-BRD7
货号：bs-7779R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 74kDa
纯化方法：affinity purified by Protein A
交叉反应：human, chicken, cow, dog, zebrafish, rhesus monkey, Orangutan
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.BRD7可能参与了基因转录调控,是一个核转录调节蛋白。经研究发现BRD7可能是通过Ras/MEK/ERK和Rb/E2F两条通路影响细胞周期的进程，使细胞停滞于G0/G1期，BRD7具有阻止细胞周期进程的作用。BRD7蛋白尤其是在鼻咽癌的发病过程中发挥了十分重要作用，BRD7基因的过表达可通过调节MAPK及Wnt信号通路YZ鼻咽癌的生长，并将鼻咽癌阻滞在G1/S期。