现货Regorafenib (BAY 73-4506) CAS号 755037-03-7_详细资料

产品信息 数量：大量规格： 2mg/5mg/10mg 规格：产品价格：￥1100 规格： 2mg 产品价格：￥1100 规格： 5mg 产品价格：￥1500 规格： 10mg 产品价格：￥2100 As a multikinase inhibitor of of angiogenic, stromal and oncogenic receptor tyrosine kinases, Regorafenib (BAY 73-4506) can inhibit c-KIT, VEGFR-2, B-Raf with IC50 of 17 nM, 40 nM and 69 nM. Regorafenib (BAY 73-4506) also inhibits additional angiogenic kinases (VEGFR1/3, platelet-derived growth factor receptor-beta and fibroblast growth fa1)Regorafenib showed an acceptable safety profile and preliminary evidence of antitumor activity in patients with solid tumors. (2)Regorafenib administered once orally at 10 mg/kg significantly decreased the extravasation of Gadomer in the vasculature of rat GS9L glioblastoma tumor xenografts.A significant reduction in tumor microvessel area was observed in a human colorectal xenograft after qdx5 dosing at 10 and 30 mg/kg. Regorafenib exhibited potent dose-dependent TGI in various preclinical human xenograft models in mice, with tumor shrinkages observed in breast MDA-MB-231 and renal 786-O carcinoma models. (3) Regorafenib showed tolerability and antitumour activity in patients with metastatic CRC. (4) Regorafenib has significant activity in patients with advanced GIST (Metastatic GI stromal tumor) after failure of both imatinib and sunitinib.ctor receptor 1) and the mutant RET. 温馨提示：不可用于临床ZL。

规格：		产品价格：	￥1100
规格：	2mg	产品价格：	￥1100
规格：	5mg	产品价格：	￥1500
规格：	10mg	产品价格：	￥2100

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现货Regorafenib (BAY 73-4506) CAS号 755037-03-7

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