Lysophosphatidic acid (LPA) exerts a variety of biological responses through specific receptors: three subtypes of the EDG-family receptors, LPA1, LPA2, and LPA3 (formerly known as EDG-2, EDG-4, and EDG-7, respectively). [1] Ki16425 is a LPA receptor inhibitor with selectivity for LPA1 (Ki = 0.34µM)and LPA3(Ki = 0.93µM)vs. LPA2(Ki = 6.5µM). [1]Ki16425 also inhibited LPA-induced longterm responses, including DNA synthesis and cell migration. [1]
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