现货，TW-37，目录号S1121，CAS号:877877-35-5，美国Selleck_详细资料

产品信息 保存条件：零下二十摄氏度低温干燥保存英文名： TW-37 CAS号： 877877-35-5 保质期：两年供应商：赛导通生物科技数量：大量规格： 10mg 信号转导通路:  细胞凋亡(Apoptosis) >> Bcl-2 >> Bcl-2 YZ剂 >> TW-37 网站链接：http://selleck.cn/tw-37-S1121.html 技术数据: 分子量(MW): 573.7 化学式: C₃₃H₃₅NO₆S 溶解度: DMSO ≥115mg/mL   Water <1mg/mL   Ethanol ≥4mg/mL 纯度: >99% 稳定性: at -20℃ 2 years CAS号: 877877-35-5 生物活性 TW-37 is a Bcl-2 protein family inhibitor with a Ki of 0.29 μM. TW-37 binds to the BH3 binding groove in Bcl-2 protein competing with BH3 peptides derived from Bid, Bim, and Bad proteins. TW-37 binds to Bcl-2 with a Ki value of 290 nM and also to Bcl-xL and Mcl-1 with high affinities. TW-37 potently inhibits cell growth in PC-3 prostate cancer cells with an IC50 value of 200 nM and effectively induces apoptosis in a dose-dependent manner. TW-37 has an IC50 of 1.1 μM for primary human endothelial cells and averaged 0.3 μM for head and neck cancer cells (OSCC3, UM-SCC-1, and UMSCC-74A). The combination of TW-37 and cisplatin showed enhanced cytotoxic effects for endothelial cells and HNSCC in vitro, compared with single agent treatment. ^[1][2] 参考文献 Antiangiogenic Effect of TW37, a Small-Molecule Inhibitor of Bcl-2 Esther Joo, Zhihong Dong, et al. Cancer Res 2006;66:8698-8706 TW-37, a small-molecule inhibitor of Bcl-2, mediates S-phase cell cycle arrest and suppresses head and neck tumor angiogenesis Benjamin D. Zeitlin, Zhaocheng Zhang, et al. Mol Cancer Ther 2009;8:893-903 客户反馈数据 MEF cells were treated for 24 hours with the Bcl-2 antagonists TW-37at the indicated doses.Acute survival was monitored by propidium iodide uptake assays(red lines).Long term survival(red line) was measured by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs). MDB-MA-231 cells were exposed to 30 um cisplatin in the absence or in thepresence of 100 nm TW-37.The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1. 如果需要长期保存，请于零下二十度低温保存。 禁止用于人体及ZL！ 特定的存储和包装每个产品的信息在产品说明书上都有注明。大多数Selleck产品，在推荐的条件下存储可稳定保存两年。产品有时建议的储存温度不同，大多数建议储存在-20 ° C ，抗体及蛋白等产品建议-60℃。YZ剂属于化学试剂，可在常温下运输储存两周左右。即使如此，我们保证产品的出货量将保持产品质量的条件下，一般都会放入冰袋。望阁下收到产品后，请按照产品数据表建议适当存储。 退换货政策 1、退换货只针对已付款用户。一张订单Selleck只提供一次退换货服务，为了确保您的权益，请考虑周全后与我们联系。 2、请您确保退换货时，商品、配件、赠品及各种包装完整。 3、因您个人原因造成的商品损坏（如自行使用、分装、受潮、变质、非原物品的等）将不予退换。 4、Selleck目前只支持商品一换一服务，换货时无法加定商品。 5、如您购买商品时Selleck上海办事处已向您提供发票，则办理退货或订单金额发生变更的换货时，请将发票随商品一同返还给Selleck上海办事处赛导通生物科技（上海）有限公司，请您妥善保管发票，如发票丢失，将无法办理退换货。 6、您的订单若办理退换货，运费金额会在您的实际退款中扣除。 温馨提示：不可用于临床ZL。

分子量(MW):	573.7
化学式:	C₃₃H₃₅NO₆S
溶解度:	DMSO ≥115mg/mL Water <1mg/mL Ethanol ≥4mg/mL
纯度:	>99%
稳定性:	at -20℃ 2 years
CAS号:	877877-35-5

	MEF cells were treated for 24 hours with the Bcl-2 antagonists TW-37at the indicated doses.Acute survival was monitored by propidium iodide uptake assays(red lines).Long term survival(red line) was measured by replacing the drug-containing media with normal media and incubating the cells until visible colonies formed.Clonogenic survival is expressed relative to the numbers of colonies formed following 24 hours incubation in normal media(lacking drugs).
	MDB-MA-231 cells were exposed to 30 um cisplatin in the absence or in thepresence of 100 nm TW-37.The cell were stained with Hoechst 33342,MitoTracker Red and Yo-pro-1.

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现货，TW-37，目录号S1121，CAS号:877877-35-5，美国Selleck

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