现货供应,Epothilone B (EPO906)，目录号S1364，CAS号:152044-54-7,细胞周期(Cell Cycle / Checkpoint),Microtubule FormationYZ剂,美国Selleck

信号转导通路:  细胞周期(Cell Cycle / Checkpoint) >> Microtubule Formation >> Microtubule Formation YZ剂 >> Epothilone B (EPO906)
http://selleck.cn/epothilone-b-S1364.html

技术数据:
分子量(MW): 507.68 
化学式: 
C27H41NO6S

溶解度: DMSO ≥102mg/mL   Water <1mg/mL   Ethanol ≥102mg/mL
纯度: >99%
稳定性: at -20℃ 2 years
CAS号: 152044-54-7

生物活性

Epothilone B (EPO906) is a new kind of cancer agents and microtubule function inhibitor with an IC50 of 3.5 nM. Epothilone B (EPO906) inhibits microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Epothilone B (EPO906)  possesses the same biological effects as paclitaxel both in vitro and in cultured cells. epothilone B suppressed microtubule dynamics in a concentration-dependent manner coincident with mitotic block. At 0.2 nm epothilone B, dynamics were not significantly altered. At 2 nm epothilone B (EPO906)  (IC33), the mean growth and shortening rates were decreased by 38 and 27%, respectively. Dynamicity was decreased by 47%. At the IC50, 80% of the cells had nearly complete stabilization of microtubule dynamics, and no anaphase or telophase figures were observed. [1][2][3]

参考文献

Suppression of microtubule dynamics by discodermolide by a novel mechanism is associated with mitotic arrest and inhibition of tumor cell proliferation Kathy Kamath, Diane Braguer, et al. Mol Cancer Ther 2003;2:1303-1311
4 The Natural Products Epothilones A and B as Lead Structures for Anticancer Drug Discovery: Chemistry, Biology,and SAR Studies KARL-HEINZ ALTMANN,ANDREAS FLORSHEIMER,et al. Progress in Medicinal Chemistr 2004;42:171-205
http://en.wikipedia.org/wiki/Epothilone http://en.wikipedia.org/wiki/Epothilone ;

客户反馈数据

 
Cells were seeded in 96 well paltes, and then treated with the indicated concentration of Epothilone B for 48h. Cell survival was measured by a standarad MTT assay. 

如果需要长期保存，请于零下二十度低温保存。
禁止用于人体及ZL！
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