美国Selleck现货供应，AZD7762 ，目录号 S1532 ，CAS号:860352-01-8, 1246094-78-9 (HCl), 1192875-06-1 (Fumaric acid) CHK YZ剂，CHK inhibitors

AZD7762 is a novel checkpoint kinase inhibitor with an IC50 of 5 and <10 nM for CHK1 and CHK2, respectively. It significantly prolonged the median time required for tumor volume doubling in response to gemcitabine and radiation. Together, findings suggest that G(2) checkpoint abrogation and homologous recombination repair inhibition both contribute to sensitization by Chk1 inhibition. Furthermore, they support the clinical use of AZD7762 in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer. ^{[1] [2]}

• Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair Leslie A. Parsels, Lili Zhao, et al. Cancer Res 2010;70:4972-4981
• AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies Chun Deng, Michael R. Grondine, et al. Mol Cancer Ther 2008;7:2955-2966

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