产品名称: | IKBKB (10A2) Antibody |
说明书: | 【点击查看详细说明及参考图片】 |
货号: | 252688 |
规格: | 0.1 ml |
产品描述: | IKBKB (Inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta, also called IKK2/IKKB) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK-beta has been shown to activate NF-kB and phosphorylate IKB-alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK-beta is essential for activation of IKK by TNF and IL1. Once activated, IKK-beta is autophosphorylated which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK-beta activity can also be regulated by MEKK-1. |
克隆类型: | Mouse Monoclonal Antibody |
亚型: | Mouse IgG1 |
免疫原: | Purified recombinant fragment of IKBKB expressed in E. coli. |
适用物种: | H |
应用范围: | WB, IHC |
应用说明: | WB: 1:500-1:2000;IHC: 1:200-1:1000; |
别名: | Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; IKBKB |
形态: | Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide. |
保存条件: | Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment. |
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