产品名称: | TrkC Antibody |
说明书: | 【点击查看详细说明及参考图片】 |
货号: | 250897 |
规格: | 0.1 mg |
产品描述: | The Trk family of nerve growth factor receptors includes Trk A, Trk B and Trk C. The prototype member of this gene family, Trk A encodes a 140-kDa cell surface receptor (gp140) expressed in neurons of the sensory spinal and cranial ganglia of neurocrest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and embryonic dorsal root ganglia. By comparison, BDNF and to a lesser extent, neurotrophin-3 (NT-3), but not NGF, can induce tyrosine phosphorylation of Trk B gp 145. Trk C, the third member of the Trk receptor family, encodes a 140-kDa protein, Trk C gp 140, that is preferentially expressed in brain tissue and primarily functions as a receptor for NT-3. An additional component of the Trk receptor complex, NGFR p 175 , binds to neurotrophic factor with low affinity but is required for efficient signaling. |
克隆类型: | Rabbit Polyclonal Antibody |
亚型: | Rabbit Ig |
免疫原: | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human TrkC. |
适用物种: | H, M, R |
应用范围: | E, WB, IHC |
应用说明: | E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500 |
别名: | NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC |
形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 5 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
保存条件: | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
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