产品名称: | CD11a (HI111) Antibody |
说明书: | 【点击查看详细说明及参考图片】 |
货号: | 250944 |
规格: | 0.1 mg |
产品描述: | The CD11a (HI111) antibody recognizes the 180-kDa integrin α chain associated with CD18, the 95-kDa integrin β2, which form a heterodimer glycoprotein called the lymphocyte function antigen-1 (LFA-1, CD11a/CD18). Leukocytes express four CD11/CD18 integrins which include a common β2 subunit and distinctive α chains. Besides CD11a/CD18, the other three integrins are known as CD11b/CD18, CD11c/CD18 and CD11d/CD18. LFA-1 is expressed on all leukocytes and is responsible for adhesion between leukocytes during immune response and transmigration of leukocytes across endothelium. The ligands for CD11a/CD18 are intercellular adhesion molecules CD54 (ICAM-1), CD102 (ICAM-2) and CD50 (ICAM-3). Patients bearing mutated CD18 genes do not express cell membrane LFA-1, a condition known as leukocyte adhesion deficiency 1 (LAD-1). |
克隆类型: | Mouse Monoclonal Antibody |
亚型: | mouse IgG1 |
免疫原: |
适用物种: | H |
应用范围: | E, FC, IHC |
应用说明: | Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500 |
别名: | Integrin alpha-L; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD11 antigen-like family member A; CD11a antigen; ITGAL; CD11A |
形态: | Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
保存条件: | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
参考文献: | Knapp W., et al., eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. P798, 1078, Oxford University Press, New York |