产品名称: | Alpha-4 Integrin Antibody |
说明书: | 【点击查看详细说明及参考图片】 |
货号: | 251867 |
规格: | 0.1 mg |
产品描述: | Integrin alpha-4 (CD49d) is a receptor for fibronectin. Integrin alpha-4 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-4 is also a receptor for VCAM1, recognizing the sequence Q-I-D-S in VCAM1, and a receptor for MADCAM1, recognizing the sequence L-D-T in MADCAM1. On activated endothelial cells, integrin alpha-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines, and also participates in cytolytic T-cell interactions with target cells. |
克隆类型: | Rabbit Polyclonal Antibody |
亚型: | Rabbit Ig |
免疫原: | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human integrin alpha-4. |
适用物种: | H, M, R |
应用范围: | E, WB, IHC, ICC |
应用说明: | E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:200; ICC: 1:50-1:100, in acetone fixed cells, antigen retrieval with pepsin and trypsin is recommended. |
别名: | Integrin alpha-4; Integrin alpha-IV; VLA-4 subunit alpha; CD49 antigen-like family member D; CD49d; ITGA4; CD49D |
形态: | Each vial contains 0.1 mg IgG in 0.5 ml (0.2 mg/ml) of PBS pH7.4, 50% glycerol. Antibody was purified by immunogen-affinity chromatography. |
保存条件: | Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
参考文献: | Prisco AR et al. 2014. Am J Physiol Heart Circ Physiol. PMID#25539711. |