Triacsin C,TRIACSIN C,76896-80-5

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产品名称：Triacsin C

产品别名：2,4,7-Undecatrienal nitrosohydrazone; 2E,4E,7E-Undecatriene-1-triazene; WS1228A

CAS号：76896-80-5

英文别名：2,4,7-Undecatrienal nitrosohydrazone; 2E,4E,7E-Undecatriene-1-triazene; WS1228A

分子量：207.27

分子式：C₁₁H₁₇N₃O

纯度：≥90%

外观：Liquid dissolved in DMSO

保存方法：Store at -20° C

描述：

Triacsin C was originally isolated from a Streptomyces aureofaciens culture. The compound is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) in intact cells and the nonspecific ACSL in cell sonicates (IC₅₀=3.6-8.7 μM). Triacsin C has been shown to inhibit de novo synthesis of triacylglycerol, diacylglycerol, cholesterol esters, and phospholipids. The inhibitory effect of Triacsin C prevents degranulation by human neutrophils through superoxide anion generation inhibition, thus inhibiting neutrophil activity. Triacsin C has been classified as a hypotensive vasodilator which may act by increasing methacholine-induced NO synthesis. The compound has also been reported to inhibit β-cells by abolishing L-type Ca²⁺ CP (L-type Ca²⁺) channel modulation.

应用：A hypotensive vasodilator, inhibitor of long-chain fatty acid acyl-CoA synthetase, neutrophils and β-cells

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