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Cripto 1 monoclonal畸胎瘤衍化生长因子单克隆抗体,抗体质量可靠,订购
Cripto 1 monoclonal畸胎瘤衍化生长因子单克隆抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称:
畸胎瘤衍化生长因子单克隆抗体英文名称:
Anti-Cripto 1 monoclonal货号:bsm-2313M
抗体来源:鼠
克隆类型:单克隆
蛋白分子量:predicted molecular weight: 21kDa
纯化方法:affinity purified by Protein A
交叉反应:hu
测试应用:ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍:The cripto gene is expressed both in ES cells and during the early phases of embryo development, while in adults it is reactivated in a wide range of epithelial cancers. It could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.Cripto-1是表皮生长因子-Cripto-FRL-Criptic(EGF-CFC)家族成员之一, 属于转化生长细胞TGF-β蛋白家族及Nodal蛋白质的共同受体。Cripto蛋白对于胚胎的发育占有非常重要的地位。 Cripto-1在人类的多种肿瘤如结肠癌、乳腺癌、卵巢癌、癌等中高表达,可激活P13K/Akt/GSK-3βc-Src和ras/raf/MAPK信号通路,介导细胞增殖和YZ细胞凋亡,Cripto蛋白的单细胞繁殖抗体,可以有效YZ一些癌细胞的生长。