序号 | 名称 | CAS | 化学名称 | 结构式 |
1 | 他达那非 | 171596-29-5 | (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
2 | 他达那非EP杂质A | NA | (6R,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
3 | 他达那非EP杂质B | NA | (6S,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
4 | 他达那非EP杂质C | NA | (6S,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
5 | 他达那非EP杂质D | NA | (6bR,12R)-12-(benzo[d][1,3]dioxol-5-yl)-12a-hydroxy-8-methyl-8,9,12,12a-tetrahydropyrazino[1',2':1,2]pyrrolo[3,4-c]quinoline-6,7,10(5H,6aH,6bH)-trione |
6 | 他达那非EP杂质E | NA | (6R,12bR)-6-(benzo[d][1,3]dioxol-5-yl)-6a-hydroxy-2-methyl-2,3,6a,7-tetrahydropyrazino[1',2':1,5]pyrrolo[3,4-b]quinoline-1,4,12(6H,12aH,12bH)-trione |
7 | 他达那非EP杂质F | NA | (8aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,8,8a-tetrahydro-1H,1'H-spiro[pyrrolo[1,2-a]pyrazine-7,4'-quinoline]-1,2',4(3'H,6H)-trione |
8 | 他达那非EP杂质G | NA | (12bR)-6-(benzo[d][1,3]dioxol-5-yl)-12-hydroxy-2-methyl-2,3-dihydropyrazino[1',2':1,5]pyrrolo[3,4-b]quinoline-1,4(6H,12bH)-dione |
9 | 他达那非EP杂质H | NA | (6R,14aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,14,14a-tetrahydrobenzo[h]pyrazino[1,2-d][1,4]diazonine-1,4,7,13(6H,8H)-tetraone |
10 | 他达那非EP杂质I | NA | (3S,8a'R)-6'-(benzo[d][1,3]dioxol-5-yl)-2'-methyl-2',3',8',8a'-tetrahydro-1'H-spiro[indoline-3,7'-pyrrolo[1,2-a]pyrazine]-1',2,4'(6'H)-trione |
11 | 他达那非杂质J | 951661-81-7 | (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide |
12 | 他达那非杂质K | 951661-84-0 | (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide |
13 | 他达那非杂质L | NA | (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid |
14 | 他达那非杂质M | NA | (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid |
15 | 他达那非杂质N | 1446144-71-3 | N-((12aR)-6-(benzo[d][1,3]dioxol-5-yl)-1,4-dioxo-3,4,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-2(1H,6H,7H)-yl)acetamide |
16 | 他达那非杂质O | 951661-85-1 | (1S,3R)-1-(benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide |
17 | 他达那非异构体杂质P | 629652-40-0 | (1S,3R)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
18 | 他达那非异构体杂质Q | 629652-42-2 | (1S,3S)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
19 | 他达那非异构体杂质R | 629652-44-4 | (1R,3S)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
20 | 他达那非异构体杂质S | 171596-44-4 | (1R,3S)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
21 | 他达那非异构体杂质T | 171596-43-3 | (1S,3S)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
22 | 他达那非异构体杂质U | 171596-42-2 | (1S,3R)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
23 | 他达那非关键中间体 碱式 | 171596-41-1 | (1R,3R)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate |
24 | 他达那非异构体杂质V | 171596-28-4 | (6S,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
25 | 他达那非异构体杂质W | 629652-72-8 | (6S,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
26 | 他达那非异构体杂质X | 171596-27-3 | (6R,12aS)-6-(benzo[d][1,3]dioxol-5-yl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
27 | 他达那非关键中间体 盐酸盐 | 171752-68-4 | (1R,3R)-methyl 1-(benzo[d][1,3]dioxol-5-yl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate hydrochloride |
28 | 氨基他达那非Y | 385769-84-6 | (6R,12aR)-2-amino-6-(benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
29 | N-乙烷基他达拉非 | 1609405-34-6 | (12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-ethyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
30 | 他达拉非氧代杂质 | 1346602-17-2 | (6R,12aR)-2-methyl-6-(2-oxobenzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
31 | 他达拉非二甲氧基杂质 | 1356345-67-9 | (6R,12aR)-6-(3,4-dimethoxyphenyl)-2-methyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
32 | 羟基丙基去甲他达拉非 | 385769-94-8 | (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-(2-hydroxyethyl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
33 | N-丁他达拉非 | 171596-31-9 | (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-butyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
34 | 乙基他达那非 | 171488-11-2 | (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-ethyl-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |
35 | D- 色氨酸甲基酯盐酸盐 | 14907-27-8 | methyl 2-amino-3-(1H-indol-3-yl)propanoate |
36 | L- 色氨酸甲基酯盐酸盐 | 7524-52-9 | (R)-methyl 2-amino-3-(1H-indol-3-yl)propanoate hydrochloride |
37 | 他达拉非 胺解杂质 | 951661-82-8 | (1R,3R)-1-(benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide |
38 | 他达拉非去甲基杂质 | 171596-36-4 | (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2,3,12,12a-tetrahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4(6H,7H)-dione |