MEP1A / Endopeptidase-2抗体

MEP1A / Endopeptidase-2抗体产品信息免疫原 :  Recombinant mouse MEP1A protein ( Catalog#50057-M08H )
 
抗体类型:  Rabbit Polyclonal Antibody ( Antibody Purification Platform ) 
抗体宿主 : Rabbit IgG
 
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation. 
制备方法 :  Produced in rabbits immunized with purified, human cell-derived, recombinant mouse MEP1A ( rM MEP1A ; Catalog#50057-M08H ; NP_032611.2 ; Met 1 - Arg 615 ). MEP1A specific IgG was purified by mouse MEP1A affinity chromatography.
MEP1A / Endopeptidase-2抗体背景综述
Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I membrane protein which belongs to the peptidase M12A family. MEP1A contains one EGF-like domain, one MAM domain, and one MATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen, and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, proteolytically processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ).
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