重组人载脂蛋白E3|APOE3 Human|Apolipoprotein E3 Human Recombinant

重组人载脂蛋白E3|APOE3 Human|Apolipoprotein E3 Human Recombinant

产品详情：CATALOGUE NUMBER

CYT-874

SYNONYMSApolipoprotein E, LDLCQ5, APO-E, LPG, AD2, Alzheimer Disease 2 (APOE*E4-Associated, Late Onset), Apolipoprotein E3, APOE.INTRODUCTIONApolipoprotein E3 (ApoE) is a 34kDa protein component of serum chylomicrons, VLDL, and HDL particles. ApoE mediates the binding, uptake, and catabolism of these particles as a result of interactions with the ApoE receptor and LDL receptors in the liver and brain. ApoE is imperative in fatty acid homeostasis and memory formation. Polymorphisms encode 3 variants (ApoE2, 3, 4), which are differentially connected to the development of atherosclerosis and neurogenerative disorders, mainly Alzheimer's disease.DESCRIPTIONAPOE3 Human Recombinant (19-317) produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 306 amino acids and having a molecular mass of 35kDa.
The APOE is fused to a 7 amino acid His tag [M-HHHHHH] at N-terminus and purified by proprietary chromatographic techniques.SOURCEEscherichia Coli.PHYSICAL APPEARANCESterile Filtered White lyophilized (freeze-dried) powder.FORMULATIONLyophilized from a 0.2µm filtered solution in PBS.SOLUBILITYIt is recommended to reconstitute the lyophilized APOE in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.STABILITYLyophilized APOE3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution APOE should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.PURITYGreater than 95% as determined by SDS-PAGE.AMINO ACID SEQUENCEMHHHHHHKVE QAVETEPEPE LRQQTEWQSG QRWELALGRF WDYLRWVQTL SEQVQEELLS SQVTQELRAL MDETMKELKA YKSELEEQLT PVAEETRARL SKELQAAQAR LGADMEDVCG RLVQYRGEVQ AMLGQSTEEL RVRLASHLRK LRKRLLRDAD DLQKRLAVYQ AGAREGAERG LSAIRERLGP LVEQGRVRAA TVGSLAGQPL QERAQAWGER LRARMEEMGS RTRDRLDEVK EQVAEVRAKL EEQAQQIRLQ AEAFQARLKS WFEPLVEDMQ RQWAGLVEKV QAAVGTSAAP VPSDNH.BIOLOGICAL ACTIVITYImmobilized rHuApoE3 binds to rMuVLDLR with EC₅₀ less than 0.4µg/ml.USAGEProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

重组人载脂蛋白E3|APOE3 Human|Apolipoprotein E3 Human Recombinant

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