1-Deoxynojirimycin Hydrochloride(1-DNJ HCL)/去氧野艽霉素盐酸盐/CAS:73285-50-4 _详细资料

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CAS号： 73285-50-4 供应商：上海佰世凯化学科技有限公司数量：大量英文名： 1-Deoxynojirimycin Hydrochloride(1-DNJ HCL) 规格： >99%

1-Deoxynojirimycin Hydrochloride(1-DNJ HCL)/ 去氧野艽霉素盐酸盐
CAS:73285-50-4
Molecular Formula: C6H13NO4.HCl
Molecular Weight: 199.63
Appearance:White crystalline powder
Purity: >99%
Biological Activity:
Many glycoproteins cannot be secreted or expressed without appropriate glycosylation and subsequent deglucosylation in the endoplasmic reticulum (ER), making α-glucosidase activity important to proper cell function. α-Glucosidases I and II remove glucose residues from N-linked oligosaccharides attached to nascent glycoproteins in the ER enabling transit to the Golgi in their properly folded form. 1-Deoxynojirimycin (hydrochloride) (1-dNM (hydrochloride)), produced by Bacillus species, is a glucose analog that potently inhibits α-glucosidase I and II. It prevents the formation of complex N-linked oligosaccharides in yeast and intact mammalian cells by inhibiting both α-glucosidase I and II with IC50 values of ~2 µM. The FDA has granted orphan drug designation to dNM (hydrochloride) for the treatment of Pompe disease, an inherited lysosomal storage disorder caused by a mutation that alters the structure and stability of α-glucosidase. 1-dNM at a concentration 0.4 mM also inhibits virus spread in HIV-infected lymphocyte cultures by interfering with α-glucosidase activity.
A specific glucosidase inhibitor including trimming glucosidases I and II, enzymes that sequentially remove the three glucose residues from precursor Glc3Man9-GlcNAc2 in N-linked glycan biosynthesis. Inhibitor of glucosidase I (Ki = 2.1 mM) and II (Ki = 7 mM).
(产品仅适用于科学实验，不得用于其他目的)

温馨提示：不可用于临床ZL。

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1-Deoxynojirimycin Hydrochloride(1-DNJ HCL)/去氧野艽霉素盐酸盐/CAS:73285-50-4

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