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CheMatech is the european leader in the design, the synthesis and the supply of chelating agents, such as DOTA derivatives, precursors of MRI contrast agents and PET and SPECT tracers.
CheMatech offers a wide range of functionalized and protected macrocycles from milligrams to hundred grams scale. CheMatech also realizes custom syntheses of new macrocyclic compounds and can take in charge the development of it's client compounds.
he Chelator makes the difference
The in-vivo imaging of a biomolecule (peptide, protein, antibody, …) often requires the grafting of a chelator prior to the radiometallation step. Recent litterarure emphasized that a small modification of the chelator can significantly alter the pharmacokinetic of the conjugate. It is especially the case when the biological molecule is a small peptide or an antibody fragment.
DOTA is a gold standard to complex most of the radiometals. However, it is by far not always the ideal candidate. It is important to find the right combination between the chelating agent and the biovector. Many factors such as the size, the geometry, the lipophilicity and the charge of the metal complex can affect the pharmacokinetic of the drug.
During the design phase of a new radiopharmaceutical, it is crucial to screen very early, which chelate will be the most adapted in order to find the ideal system: chelator/radiometal/biovector.
All these considerations lead us to provide you several samples packs in order to give you the opportunity to test different chelating agents in a cost effective way.
Maleimide Pack
Chelating agents bearing Maleimide function. Specific reactivity toward SH group such ascysteine.
50 mg Maleimide-DOTA
50 mg Maleimide-DOTA-GA
50 mg Maleimide-NOTA
50 mg Maleimide-NODA-GA
50 mg Maleimide-DTPA
Activated Esters Pack
Chelating agents bearing NHS ester or anhydride groups. Specific reactivity toward NH2group such as lysine.
50 mgDOTA-NHS ester
50 mg NOTA-NHS ester
50 mg NODA-GA-NHS ester
50 mg DOTA-GA- anhydride
50 mg DTPA anhydride
Protected Chelators Pack
Selectively (tBu) ester protected chelating agents.
100 mg DOTA-tris(tBu)ester
100 mg DOTA-GA-t(Bu)4
100 mg NOTA-bis(tBu)ester
100 mg NODA-GA-tris(tBu)ester
100 mg DTPA-tetra(tBu) ester
温馨提示:不可用于临床ZL。