类胰岛素一号增长因子/促生长因子_详细资料

产品信息

保存条件： -20℃ 供应商：上海惠诚生物科技有限公司保质期：两周数量： 1mg

Cat. Number kx-GMP-034

Chemical Name IGF1,类胰岛素一号增长因子/促生长因子，Recombinant LR3-IGF-1 protein

Category Protein

Qty 1 1mg

Appearance 白色无菌冻干粉剂

Application Notes 生物学活性：大于1.0 x 106IU/mg.纯度大于97.0%.

Synonym LR3-IGF1

Storage condition -20℃

Stability 建议将冻干rhIGF-1溶解在注射用水或灭菌的超纯水中，浓度不低于100μg/ml，以待进一步稀释至工作浓度。避免反复冻融。复溶后的细胞因子：4℃可稳定储存7-10天；长期保存请分装后存放于-20℃。

References
IGF1,类胰岛素一号增长因子/促生长因子，Protein, Human, Recombinant

IGF （insulin-like growth factors），中文翻译为胰岛素样生长因子或“类胰岛素生长因子”，因其结构与胰岛素类似而得名；也被称为“生长激素介质”（即SM ，somatomedins）。是生长激素产生生理作用过程中必须的一种活性蛋白多肽物质。
上海惠诚生物提供IL-1F5 Protein, Human, Recombinant (Native) 以及各类细胞因子，同时推出CHO稳定细胞株开发技术服务方案，详情咨询电话021-60498804.
上海惠诚生物提供的 IGF1由真核细胞表达的重组蛋白，是将蛋白基因接入稳定表达载体，转化CHO-K1细胞，经克隆筛选，质量验证，挑选的稳定表达株，由化学成分确定的培养基（不含有任何动物源成分）发酵制备，工艺稳定，保证了产品质量及批次间的一致性。

本产品为无菌冻干粉剂，由含有10mMPBS pH为7.2的蛋白溶液经0.2μm过滤后分装冻干。

规格参数：

货号：KX-GMP-034      规格：50μg/1mg.

质量控制：

生物学活性：大于1.0 x 106IU/mg.

纯      度：经GX液相色谱（SEC-HPLC）和SDS-PAGE检测，纯度大于97.0%.

内  毒  素：小于5EU/mg.

使用说明：

建议将冻干rhIGF-1溶解在注射用水或灭菌的超纯水中，浓度不低于100μg/ml，以待进一步稀释至工作浓度。避免反复冻融。

复溶后的细胞因子：4℃可稳定储存7-10天；长期保存请分装后存放于-20℃。

Background Information：
IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.

上海惠诚生物提供 IGF1,类胰岛素一号增长因子/促生长因子，Protein, Human, Recombinant 以及各类细胞因子，同时推出CHO稳定细胞株开发技术服务方案，详情咨询电话021-60498804.

温馨提示：不可用于临床ZL。

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Cat. Number	kx-GMP-034
Chemical Name	IGF1,类胰岛素一号增长因子/促生长因子，Recombinant LR3-IGF-1 protein
Category	Protein
Qty 1	1mg
Appearance	白色无菌冻干粉剂
Application Notes	生物学活性：大于1.0 x 106IU/mg.纯度大于97.0%.
Synonym	LR3-IGF1
Storage condition	-20℃
Stability	建议将冻干rhIGF-1溶解在注射用水或灭菌的超纯水中，浓度不低于100μg/ml，以待进一步稀释至工作浓度。避免反复冻融。复溶后的细胞因子：4℃可稳定储存7-10天；长期保存请分装后存放于-20℃。
References	IGF1,类胰岛素一号增长因子/促生长因子，Protein, Human, Recombinant IGF （insulin-like growth factors），中文翻译为胰岛素样生长因子或“类胰岛素生长因子”，因其结构与胰岛素类似而得名；也被称为“生长激素介质”（即SM ，somatomedins）。是生长激素产生生理作用过程中必须的一种活性蛋白多肽物质。上海惠诚生物提供IL-1F5 Protein, Human, Recombinant (Native) 以及各类细胞因子，同时推出CHO稳定细胞株开发技术服务方案，详情咨询电话021-60498804. 上海惠诚生物提供的 IGF1由真核细胞表达的重组蛋白，是将蛋白基因接入稳定表达载体，转化CHO-K1细胞，经克隆筛选，质量验证，挑选的稳定表达株，由化学成分确定的培养基（不含有任何动物源成分）发酵制备，工艺稳定，保证了产品质量及批次间的一致性。本产品为无菌冻干粉剂，由含有10mMPBS pH为7.2的蛋白溶液经0.2μm过滤后分装冻干。规格参数：货号：KX-GMP-034 规格：50μg/1mg. 质量控制：生物学活性：大于1.0 x 106IU/mg. 纯度：经GX液相色谱（SEC-HPLC）和SDS-PAGE检测，纯度大于97.0%. 内毒素：小于5EU/mg. 使用说明：建议将冻干rhIGF-1溶解在注射用水或灭菌的超纯水中，浓度不低于100μg/ml，以待进一步稀释至工作浓度。避免反复冻融。复溶后的细胞因子：4℃可稳定储存7-10天；长期保存请分装后存放于-20℃。 Background Information： IGF I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation. 上海惠诚生物提供 IGF1,类胰岛素一号增长因子/促生长因子，Protein, Human, Recombinant 以及各类细胞因子，同时推出CHO稳定细胞株开发技术服务方案，详情咨询电话021-60498804.