财盛生物|bioxcell人种属体内注射PD-L1抗体InVivoMAb anti-human PD-L1 (B7-H1)_详细资料

产品信息

供应商：广州财盛生物英文名： Prosperich 规格： 1 mg

本产品有1、5、25、50、100mg规格、部分有现货；欢迎咨询！About InVivoMAb anti-human PD-L1 (B7-H1)The 29E.2A3 monoclonal antibody reacts with human PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the Ig superfamily. PD-L1 is expressed on T lymphocytes, B lymphocytes, NK cells, dendritic cells, as well as IFNγ stimulated monocytes, epithelial cells and endothelial cells. PD-L1 binds to its receptor, PD-1, found on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Engagement of PD-L1 with PD-1 leads to inhibition of TCR-mediated T cell proliferation and cytokine production. PD-L1 is thought to play an important role in tumor immune evasion. Induced PD-L1 expression is common in many tumors and results in increased resistance of tumor cells to CD8 T cell mediated lysis. The 29E.2A3 antibody has been shown to block the binding of PD-1-Ig to PD-L1.

Isotype Mouse IgG2b, κ

Recommended Isotype Control(s) InVivoMAb mouse IgG2b isotype control, unknown specificity(BE0086)

Recommended InVivoPure Dilution Buffer InVivoPure pH 7.0 Dilution Buffer(IP0070)

Immunogen Full length human PD-L1

Reported Applications

in vitro PD-L1 blockade

Functional assays

Immunohistochemistry (frozen)

Flow cytometry

Endotoxin

<2EU/mg (<0.002EU/μg)

Determined by LAL gel clotting assay

Purity

>95%

Determined by SDS-PAGE

Formulation

PBS, pH 7.0

Contains no stabilizers or preservatives

Sterility 0.2 μM filtered

Production Purified from tissue culture supernatant in an animal free facility

Purification Protein G

Storage The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

RRID AB_2687808

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财盛生物|bioxcell人种属体内注射PD-L1抗体InVivoMAb anti-human PD-L1 (B7-H1)

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Isotype	Mouse IgG2b, κ
Recommended Isotype Control(s)	InVivoMAb mouse IgG2b isotype control, unknown specificity(BE0086)
Recommended InVivoPure Dilution Buffer	InVivoPure pH 7.0 Dilution Buffer(IP0070)
Immunogen	Full length human PD-L1
Reported Applications	in vitro PD-L1 blockade Functional assays Immunohistochemistry (frozen) Flow cytometry
Endotoxin	<2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay
Purity	>95% Determined by SDS-PAGE
Formulation	PBS, pH 7.0 Contains no stabilizers or preservatives
Sterility	0.2 μM filtered
Production	Purified from tissue culture supernatant in an animal free facility
Purification	Protein G
Storage	The antibody solution should be stored undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.
RRID	AB_2687808