L1 NCAM Monoclonal Antibody_详细资料

产品信息

靶点：来电咨询浓度： 1mg/1ml 应用范围：科研使用宿主： Goat，Rabbit，Mouse 适应物种：人，大鼠，小鼠，兔标记物：见说明书克隆性：多克隆保存条件： -20℃保存形态：液态/粉状

L1 NCAM Monoclonal Antibody保存于运输说明：

Store at -20°C

详细信息：

Description Monoclonal Antibody against L1 NCAM

Clone 74-5H7

Form Ascites

Host Mouse

Species Reactivity Mammalian, Chicken

IsoType L1 NCAM Monoclonal AntibodyIgG1

[Ab] 2-3 mg/mL

Specificity The cell adhesion molecule L1 is a 200-220 kD protein of the immunoglobulin superfamily. It participates in a wide variety of neuronal functions including migration, outgrowth, synaptogenesis and myelination. This monoclonal antibody was raised against purified chick L1, and binds to the L1 cytoplasmic domain at about T1172 (adjacent to the YRSL sorting signal). Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain.

Uses This antibody is effective in immunoblotting, immunoprecipitation and immunohistochemistry.

Suggested Working Dilution The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval.

L1 NCAM Monoclonal AntibodyWestern blot    1:2000*
Immunoprecipitation   1:500
Immunohistochemistry   1:500**

Notes *Predicted MW = 200-220 kD
**Recommend using Bouin’s fixative as outlined in the Kamiguchi et al. reference.

Storage Store at -20°C. It is suggested that the total volume be divided into useable aliquots upon initial thaw.

References H Kamiguchi, KE Long, M Pendergast, AW Schaefer, I Rapoport, T Kirchhausen, V Lemmon. The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway. J. Neurosci. 18(14):5311-21, 1998.

V Lemmon, KL Farr, C Lagenaur. L1-mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron. 2(6):1597-603, 1989.

PM Yip, CH Siu. PC12 cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth. J. Neurochem. 76(5):1552-1564, 2001.

Warranty/Conditions Covance products may not be resold or modified for resale without prior written approval.

L1 NCAM Monoclonal Antibody

xy-7835R   Bub3有丝分裂蛋白BUB3抗体
xy-11653R   BHLHB9/p60TRPp60TRP蛋白抗体
xy-11654R   BLMH博莱霉素水解酶抗体
xy-11655R   Aggrecan短蛋白聚糖抗体
xy-8397R   BTBD3BTB/POZ结构域蛋白3抗体
xy-11505R   BBS12巴尔得-别德尔综合征相关蛋白12抗体
xy-12903R   BZW1碱性亮氨酸拉链蛋白BZW1抗体
xy-6639R   BMPR1B骨形态发生蛋白受体1B抗体
xy-6681R   BNIP1Bcl2相互作用蛋白1抗体（转化相关基因8蛋白）
xy-6614R   BMP5骨形态发生蛋白5抗体
xy-6612R   BMP15骨形态发生蛋白15抗体
xy-5903R   Bcl2L2Bcl-2样蛋白2抗体
xy-4292R   BPI杀菌/通透性增强蛋白抗体
xy-4563R   Bcl-2Bcl-2抗体
xy-8202R   BRN4脑转录因子4蛋白抗体
xy-5042R   Bile salt-activated lipase胆盐激活脂肪酶抗体
xy-5041R   BDH13-羟丁酸脱氢酶抗体
xy-5040R   BAAT长链脂肪酸酰基辅酶A水解酶抗体
xy-8444R   Phospho-BRCA1(Ser988)磷酸化乳腺癌易感基因1抗体
xy-5215R   phospho-BACE1 (Ser498)磷酸化β分泌酶抗体
xy-5216R   Phospho-Bad (Ser118)磷酸化相关死亡促进因子抗体
xy-5217R   Phospho-Bad (Ser134)磷酸化相关死亡促进因子抗体
xy-5220R   Phospho-Bcl-2(Thr129)磷酸化Bcl-2抗体
xy-5221R   Phospho-BRCA1 (Ser1189)磷酸化乳腺癌易感基因1抗体
xy-5222R   Phospho-BRCA1 (Ser1423)磷酸化乳腺癌易感基因1抗体
xy-5223R   Phospho-BMX (Tyr556)磷酸化非受体性蛋白酪氨酸激酶ETK抗体
xy-5224R   phospho-B-Raf (Thr401)磷酸化B-Raf抗体
xy-4092R   BACH1乳腺癌易感基因相互作用蛋白1抗体
xy-5226R   phospho-BACH1 (Ser990)磷酸化乳腺癌易感基因相互作用蛋白1抗体
xy-5219R   phospho-BAD (Ser99)磷酸化相关死亡促进因子抗体
xy-5230R   phospho-Bid (Ser65)磷酸化BH3结构域凋亡诱导蛋白抗体
xy-5231R   phospho-Bid (Ser61)磷酸化BH3结构域凋亡诱导蛋白抗体
xy-5232R   phospho-B-Raf (Ser446)磷酸化B-Raf抗体

您可能感兴趣的产品

L1 NCAM Monoclonal Antibody

产品信息

联系我们

关注我们

Description		Monoclonal Antibody against L1 NCAM
Clone		74-5H7
Form		Ascites
Host		Mouse
Species Reactivity		Mammalian, Chicken
IsoType		L1 NCAM Monoclonal AntibodyIgG1
[Ab]		2-3 mg/mL
Specificity		The cell adhesion molecule L1 is a 200-220 kD protein of the immunoglobulin superfamily. It participates in a wide variety of neuronal functions including migration, outgrowth, synaptogenesis and myelination. This monoclonal antibody was raised against purified chick L1, and binds to the L1 cytoplasmic domain at about T1172 (adjacent to the YRSL sorting signal). Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain.
Uses		This antibody is effective in immunoblotting, immunoprecipitation and immunohistochemistry.
Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval. L1 NCAM Monoclonal AntibodyWestern blot 1:2000* Immunoprecipitation 1:500 Immunohistochemistry 1:500**
Notes		Predicted MW = 200-220 kD *Recommend using Bouin’s fixative as outlined in the Kamiguchi et al. reference.
Storage		Store at -20°C. It is suggested that the total volume be divided into useable aliquots upon initial thaw.
References		H Kamiguchi, KE Long, M Pendergast, AW Schaefer, I Rapoport, T Kirchhausen, V Lemmon. The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway. J. Neurosci. 18(14):5311-21, 1998. V Lemmon, KL Farr, C Lagenaur. L1-mediated axon outgrowth occurs via a homophilic binding mechanism. Neuron. 2(6):1597-603, 1989. PM Yip, CH Siu. PC12 cells utilize the homophilic binding site of L1 for cell-cell adhesion but L1-alphavbeta3 interaction for neurite outgrowth. J. Neurochem. 76(5):1552-1564, 2001.
Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.