Biological Activity
PD169316 is a potent, cell-permeable, and high selective p38 MAPK inhibitor (IC50 = 89 nM),and the IC50s are >100-fold higher for ERK, >1,000-fold higher for PKA and PKCα [1]. PD169316 dose-dependently attenuates apoptosis in potassium-deprived rat cerebellar granule neurons [2],and markedly decreases p38 activity and apoptosis in trophic factor-derived rat-1 fibroblasts and PC12 cells [3]. PD 169316 (5 μM or higher) inhibits TGFbeta-induced Smad signaling in human ovarian cancer cells [4] .PD 169316 decreases synaptosomal 5-HT uptake in a dose- and time-dependent manner,and suppresses SERT expression [5].
Chemical Properties
| Cas No.: 152121-53-4 | M. Wt.: 360.3 |
| Formula: C20H13FN4O2 | Purity: >98% (HPLC) |
| Chemical Name: 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole |
| Appearance: Orange-yellow solid |
| Solubility：Soluble in DMSO (10 mg/ml) |
| Storage：Store solid at -20 ºC for the stability of two years, prevent from light. |
Application Concentration (Just for reference)
The appropriate working concentration of PD169316 depends on cell types, cell culture properties and specific applications. It is recommended that researchers start with optimal experiments for first use.
温馨提示：不可用于临床ZL。
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