氯喹 Chloroquine diphosphate salt

【英文同义名】 ： Chloroquine Diphosphate, Chloroquine phosphate, Aralen phosphate, Chingamin phosphate, Arechin

【中文同义名】 ：二磷酸氯喹

产品描述

Chloroquine diphosphate salt 是 Chloroquine 的 二磷酸盐型式。 Chloroquine 是抗疟疾和抗风湿剂，也是ATM活化剂  ^[1]。ChloroquineYZ钾离子通道内向整流，其机制包括离子通道门控变构和阻断  ^[2]_。  Chloroquine能显著增加肺动脉内皮细胞（PAEC）细胞表面BMPR-II蛋白的独立转录，能显著增加突变 BMPR-II PAEC细胞和血液增生内皮细胞BMP9-BMPR-II信号通路靶点Id1, miR21和miR27a的表达^[3]。在原位移植（U87MG）人成胶质细胞瘤小鼠模型中，Chloroquine能激活p53通路，YZ细胞生长。Chloroquine也能诱导人脑胶质瘤细胞凋亡  ^[4]。

Chloroquine diphosphate salt 的具 体使用浓度请参考相关文献，并根据自身实验条件（如实验目的，细胞种类，培养特性等）进行摸索和优化。

[1] Slater AF. Chloroquine: mechanism of drug action and resistance in Plasmodium falciparum. Pharmacol Ther. 57(2-3):203-35 (1993).

[2]   Ponce-Balbuena D , et al.   Molecular Mechanisms of Chloroquine Inhibition of Heterologously Expressed Kir6.2/SUR2A Channels. Molecular Pharmacology. 82(5):803-813 (2012).

[3] Dunmore BJ , et al.   The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations. Human Molecular Genetics. 22(18):3667-3679 (2013).

[4] Kim EL , et al.   Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells. Neuro-Oncology. 12(4):389-400 (2010).