Flamma® NIR Flours系列近红外荧光染料

描述

BioActs的Flamma^®  NIR Flours系列是近红外荧光染料，用于动物成像。BioActs的产品有高荧光强度、水溶性好及低毒性的优点。BioActs的近红外荧光染料波长范围为 600到900 nm, 在动物体内可GX成像。

BioActs的近红外染料有各种反应基团，如NHS酯，马来酰亚胺等，所以你可以选择合适的反应基团进行有效的实验。

[Figure 2] 选择反应基团与带氨基的生物材料反应

[Figure 3] 选择反应基团与带巯基的生物分子反应

产品清单

近红外荧光染料体内成像实验步骤

实验步骤如下
实验准备: 5周龄的Balb/c 雄性裸鼠(1周稳定期后，在第六周实施实验)
动物实验: 稀释每种荧光材料，浓度为0.03 mg / ml.，静脉注射 100 μl 荧光材料到鼠体内。在注射后 1 分钟, 30 分钟, 1 小时, 2 小时, 3 小时, 和 1 天后分别对其荧光成像. (成像设备: IVIS)

体内实验结果

[Figure 4] Flamma^®  749 Carboxylic acid 注入鼠体内, 一天内被清除

[Figure 5] Flamma^®  774 Carboxylic acid 注入鼠体内, 一天内被清除

[Figure 6] ICG Carboxylic acid注入鼠体内, 一天内在体内被清除

参考文献

Paclitaxel loaded hyaluronic acid nanoparticles for targeted cancer therapy: In vitro and in vivo analysis (Reju G. Thomas, , MyeongJu Moon, SeJy Lee, Yong Yeon Jeong, International Journal of Biological Macromolecules, 2015, Volume 72, Pages 510–518)
Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery (Hong Yeol Yoona, Heebeom Koo, Ki Young Choi, Ick Chan Kwon, Kuiwon Choi, Jae Hyung Park, Biomaterials, 2013, Volume 34, Issue 21, Pages 5273–5280) 
Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo (So Jin Lee, Simmyung Yook, Ji Young Yhee, Hong Yeol Yoon, Myung-Goo Kim, Sook Hee Ku, Sun Hwa Kim, Jae Hyung Park, Ji Hoon Jeong, Ick Chan Kwon, Seulki Lee, Hyukjin Lee, Kwangmeyung Kim, Journal of Controlled Release, 2015, Volume 220, Part B, Pages 631–641) 
Effectiveness of Losartan-Loaded Hyaluronic Acid (HA) Micelles for the Reduction of Advanced Hepatic Fibrosis in C3H/HeN Mice Model (Reju George Thomas, Myeong Ju Moon, Jo Heon Kim, Jae Hyuk Lee, Yong Yeon Jeong, PLoS ONE, 2015, 10(12): e0145512.)
Notch1 targeting siRNA delivery nanoparticles for rheumatoid arthritis therapy (Min Ju Kim, Jong-Sung Park, So Jin Lee, Jiyeon Jang, Jin Su Park, Seung Hyun Back, Gahee Bahn, Jae Hyung Park, Young Mo Kang, Sun Hwa Kim, Ick Chan Kwon, Dong-Gyu Jo, Kwangmeyung Kim, Journal of Controlled Release, 2015, Volume 216, Pages 140–148) 
Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance (Ji Young Yhee, Seungyong Song, So Jin Lee, Sung-Gurl Park, Ki-Suk Kim, Myung Goo Kim, Sejin Son, Heebeom Koo, Ick Chan Kwon, Ji Hoon Jeong, Seo Young Jeong, Sun Hwa Kim, Kwangmeyung Kim, Journal of Controlled Release, 2015, Volume 198, Pages 1–9) 
A new fluorescence/PET probe for targeting intracellular human telomerase reverse transcriptase (hTERT) using Tat peptide-conjugated IgM (Kyung oh Jung, Hyewon Youn, Seung Hoo Kim, Young-Hwa Kim, Keon Wook Kang, June-Key Chung, Biochemical and Biophysical Research Communications, 2016, Volume 477, Issue 3, Pages 483–489) 
Controlled Release of Hepatocyte Growth Factor from MPEG-b-(PCL-ran-PLLA) Diblock Copolymer for Improved Vocal Fold Regeneration (Jae Won Choi, Yeon Soo Kim, Ju Kyeong Park, Eun Hye Song, Ji Hoon Park, Moon Suk Kim, Yoo Seob Shin, Chul-Ho Kim, Macromolecular Bioscience, 2016, DOI: 10.1002/mabi.201600163)